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It’s a real challenge for the folks on the ground to fit their reality into the prescribed format of a Federal grant.

The first trials did not demonstrate effectiveness beyond placebo. So the FDA allowed a third trial which apparently did, at least a little.

We shouldn’t ignore the emotional factors involved in chronic pain– such as anxiety and depression.

The list of deaths from the practice is long and oddly prestigious, featuring celebs such as John Belushi and Chris Farley, among many others.

If the dose is in fact subtherapeutic, then what causes the effects so enthusiastically reported by the user?

The best answer is the one we came up with to explain the selectivity of alcoholism: Differences in individual susceptibility.

Will society benefit from greater access to this drug? Are there potential problems we haven’t anticipated?

This is in part a course correction from the trend of several decades ago, when the emphasis was on cutting expenses in the naive belief all addicts could be successfully treated on an outpatient basis.

I compare it to finding someone lying on the sidewalk, helping them up, brushing them off, and pushing them down again.

Many so-called “heavy drinkers” do in fact meet criteria for an AUD, but quite a few do not.